Weeding Mendel’s Garden: Can We Hoe Dubious Genetic Associations?
factor for LOAD (Aldudo et al., 1998; Zekanowski et al., 2004; Helisalmi et al., 2000). Other presenilin
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“Network Epicenters” in Healthy Connectome Predict Dementia
June 2012. Preview by Warren et al., 2012 Raj et al., 2012 Zhou et al., 2012 Read a series of questions
Who Should Use the New Diagnostic Guidelines? The Debate Continues
covered this important milestone with commentary (see Dubois et al., 2007), in the news (see ARF related
Adding Dynamics and Nuance to Alzheimer’s Staging
(i.e., their evolution over the course of the disease) (Jack et al., 2010; Weiner et al., 2010; Frisoni
Clearing the Fog Around Aβ Oligomers
concentrations (see ARF related news story and Lambert et al., 1998). Soon, numerous other labs fingered Aβ
Resolving Controversies on the Path to AD Therapeutics
pharma picks them up for human translation (Prinz et al., 2011). Hyped coverage of such publications can
Slow Aβ; Clearance Is ApoE4’s Modus Operandi in Late-Onset AD
Aβ production that might be regulated by synaptic activity (Kamenetz et al., 2003; Bero et al., 2011)
Intraneuronal Aβ: Was It APP All Along?
(Seubert et al., 1992; Haass et al., 1992). All the same, a parallel line of inquiry challenging the
Two New Sets of Diagnostic Criteria—Which Is Right for Your Clinic?
phases (see ARF related news story on McKhann et al., 2011; Albert et al., 2011; and Sperling et al.,
Volunteers Help Scientists Explore Down’s, Alzheimer’s Nexus
influence biology in people with Down’s (see Korbel et al., 2009), the presence of an extra copy of the gene
Grasping the Shadow Force: Immune Cells in ALS
related news story on Lincecum et al., 2010). Compounds that block the interaction between CD40 and its
Reimagining Alzheimer's Disease—Time for Bright New Ideas?
Alois Alzheimer made a major breakthrough when he discovered senile plaques in the brains of dementia patients, and his work ultimately led to the discovery of amyloid-β and to the amyloid cascade hypothesis. But that cascade is only part of a much bigger
Herpes Simplex and Alzheimer’s—Time to Think Again?
in the brains of wild-type mice infected with Chlamydia pneumoniae (Little et al., 2004). More
Stress Granules and Neurodegenerative Disease—What’s the Scoop?
knocking down (Mokas et al., 2009) or inhibiting (Kedersha et al., 1999) key translation factors, or by
Focus on the Locus! (Ceruleus, That Is, in Alzheimer’s Disease)
disease (Mann et al., 1980; Bondareff et al., 1982; Haglund et al., 2006). Tau pathology also occurs in LC
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